CONTEXT: Peer reviewed paper reporting on a non-interventional study in COPD treatment outcomes | Patient reported outcomes using the Clinical COPD Questionnaire (CCQ) from 4700 patients
IMPACT: Medium
READ TIME: 2 mins
Quality Level Mean [1 – 10]: 8
1. “After 6 weeks of treatment with tiotropium/olodaterol, over 80% of the patients we surveyed had better clinical control of COPD, defined as a decrease in CCQ score of 0.4 points, compared with at the start of the study.”
2. “The aim of this non-interventional study (NCT03663569) was to prospectively investigate the potential changes in clinical control using the CCQ when patients with COPD (either treatment-naïve or those receiving LAMA or LABA monotherapy or LABA/inhaled corticosteroids [ICS] at baseline) were receiving treatment with tiotropium/olodaterol for 6 weeks in routine clinical practice.”
3. “The primary endpoint was the occurrence of therapeutic success, predefined as a 0.4-point decrease in the total CCQ score between Visit 1 (baseline visit) and Visit 2 (final visit, approximately 6 weeks after starting treatment; this correlates with the average time before the next pulmonologist consultation after an initial prescription of an inhaler therapy for COPD).”
4. “The minimal clinically important difference (MCID) of the CCQ total score is −0.4.23. All analyses for the primary and secondary endpoints were descriptive and were performed on the full analysis set (FAS), which comprised patients with informed consent and at least one documented administration of tiotropium/olodaterol and available total CCQ score data at Visits 1 and 2.”