CONTEXT: Report of data presented at ASCO 2021 on cetuximab in metastatic colorectal cancer (mCRC) | US only data
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Quality Level Mean [1 – 10]: 7
1. “Moreover, receiving second-line treatment with cetuximab plus FOLFIRI (median TOT = 4.43 months; mIQR, 3.71-5.36), having KRAS wild-type status, and receiving second-line cetuximab following frontline capecitabine plus oxaliplatin (CAPOX), were all associated with a longer median TOT.”
2. “In patients with metastatic colorectal cancer (mCRC) who received cetuximab (Erbitux) as a second-line therapy after irinotecan or oxaliplatin-based regimens have failed, KRAS mutational status and geographical region were associated with time on treatment (TOT), while body mass index (BMI) and age were linked with overall survival (OS), according to data from a real-world retrospective analysis.”
3. “Results, which were presented during the 2021 ASCO Annual Meeting,indicated that the median TOT in patients who received second-line cetuximab was 3.94 months (median interquartile range [mIQR], 3.51-4.40), while the median OS was 14.36 months (mIQR, 13.01-15.70).”
4. “Having a higher BMI was associated with a longer median OS (obese vs underweight HR, 0.46; 95% CI, 0.32-0.66), while receiving treatment with second-line cetuximab plus 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) was linked with a shorter median OS (10.97 months; mIQR, 5.55-14.06).”
5. “Anti-epidermal growth factor receptor drugs are being increasingly utilized in later lines of therapy in patients with mCRC, but the real-world TOT and OS of patients who receive cetuximab in second-line setting has not been examined.”