CONTEXT:  Peer reviewed article | RWR uncovering potential diagnostic bias in NASH diagnoses again illustrates the power of large data sets in real-world settings to help physicians target the best diagnostic tools | TARGET‐NASH is a longitudinal observational cohort of pediatric and adult patients with NAFLD managed at academic (i.e., teaching hospitals/universities) and community (i.e., private practice) sites in the United States, representing hepatology, gastroenterology, and endocrinology practices

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1. “DURHAM, N.C., Feb. 22, 2021 /PRNewswire/ — Target RWE, a leading real-world evidence (RWE) solutions company for the pharmaceutical and biotech industries, announced newest data from its ongoing nonalcoholic steatohepatitis (NASH) observational study, published in Hepatology Communications 3,474 participants with NAFLD from August 2016 to March 2019, the study found 67% had not had a liver biopsy.” 

2. “The TARGET-NASH study, Patient Determinants for Histologic Diagnosis of Nonalcoholic Fatty Liver Disease in the Real World: A TARGET-NASH Study, aimed to determine patient characteristics that are predictive of having a diagnosis by biopsy versus a diagnosis using clinical criteria.” 

3. “Analyzing 3,474 adult participants with nonalcoholic fatty liver disease (NAFLD) managed in usual clinical practice from August 2016 to March 2019, the study found 67% of the cohort had not had a liver biopsy.” 

4. “”It is critical to better understand the source of the histological diagnosis of NAFLD/NASH as the FDA inches closer to medication approval and patients could be treated based on non-invasive clinical 766 patients were diagnosed based on clinical criteria which highlights the need to utilize pragmatic diagnostic criteria for NASH,” said Arun Sanyal, MD, Professor, Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, and senior author.” 

5. “TARGET-NASH is a longitudinal study of adult and pediatric participants with NAFLD and/or NASH in usual clinical practice.” 

Source URL: https://www.biospace.com/article/releases/target-nash-real-world-study-reveals-two-thirds-of-patients-with-nafld-had-no-record-of-liver-biopsy/

URL2: https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep4.1689