Canadian COVID vaccine study concludes Pfizer, Moderna and AZ all provide good protection against variants of concern.

CONTEXT:  Real-world research study in Canada using vaccination, laboratory testing and health administration databases shows Pfizer, Moderna and AZ COVID vaccines are effective against all 4 variants of concern.  The study looked at Alpha, Beta, Gamma and Delta VOCs during December 2020 to May 2021.  The findings showed even a single dose of any of the 3 vaccines provide good to excellent protection against infection and severe outcomes.

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1. “Against the Delta variant, vaccine effectiveness after partial vaccination was lower than that against the Alpha variant for BNT162b2 and mRNA-1273 but was similar to the Alpha variant for ChAdOx1.” 

2. “Toronto-based researchers recently conducted a study to determine the effectiveness of BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), and ChAdOx1 (AstraZeneca) vaccines against symptomatic COVID-19 infection caused by the Alpha, Beta, Gamma, and Delta variants between December 2020 to May 2021.” 

3. “The results showed that vaccine effectiveness with partial vaccination or ≥14 days after dose 1 was higher for mRNA-1273 compared to BNT162b2 and ChAdOx1 against symptomatic infection caused by the Alpha variant.” 

4. “The vaccine effectiveness estimates from this study against symptomatic infection with Alpha and Beta/Gamma variants after partial vaccination with mRNA or ChAdOx1 vaccines agree with that in British Columbia.” 

5. “According to the authors, the findings show that even partial vaccination by all three vaccines provides good to excellent protection against symptomatic infection and severe disease caused by all four currently circulating VOCs, and that full vaccination or two doses of all three vaccines are likely to offer even higher protection against all VOCs.” 

Source URL: https://www.medrxiv.org/content/10.1101/2021.06.28.21259420v1