CONTEXT: RWE data presented at the Digestive Disease Week (DDW) 2021 evaluated the prevalence and predictors of immunomodulator use as concomitant therapy with two commonly prescribed biologics.
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1. “It is a serious limitation of biologic therapy used to treat inflammatory bowel disease such as Crohn’s disease (CD) or ulcerative colitis (UC),” said Megan Lutz, MD, Fellow at the University of Wisconsin School of Medicine and Public Health and lead author.”
2. “DURHAM, N.C., May 23, 2021 /PRNewswire/ — Research presented today at Digestive Disease Week (DDW) 2021 evaluated the prevalence and predictors of immunomodulator use as concomitant therapy with two commonly prescribed biologics, vedolizumab (Entyvio) or ustekinumab (Stelara), in patients with inflammatory bowel disease (IBD).”
3. “Data from Target RWE’s TARGET-IBD large longitudinal cohort Immunomodulators are Commonly Used as Concomitant Therapy with Vedolizumab or Ustekinumab: TARGET-IBD Real World Cohort was selected for the Poster of Distinction Award.”
4. “”We need to further research efficacy and safety of using an immunomodulator in conjunction with newer biologic therapies such as ustekinumab or vedolizumab to decrease immunogenicity in patients with IBD, since we could avoid unnecessary risks with otherwise generally safe therapies.””
5. “A separate study from TARGET-IBD, Biologic-naïve Patients with Crohn’s Disease are More Likely to Achieve Mucosal Healing than Biologic-experienced Patients: TARGET-IBD Real World Cohort, found that, consistent with observations from clinical trials, biologic-naive patients in a real-world CD cohort were significantly more likely to achieve mucosal healing than biologic-experienced patients.”